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1.Ph.D. in BiologicalScience (2001-2005) Department of Biological Science, National Sun Yat-Sen University, Kaohsiung, ROC

2.M.A. in BiologicalScience (1998-2001) Department of Biological Science, National Sun Yat-Sen University, Kaohsiung, ROC

3.B.S. in Occupational Therapy (1992-1996) Department of Rehabilitation Medicine, Kaohsiung Medical College, Kaohsiung, ROC

Clinical Training

Department of Rehabilitation Medicine, Kaohsiung Chung-Ho Memorial Hospital, Kaohsiung, ROC

1.Assistant Professor2006.7-present Department of Occupational Therapy, I-Shou University, Kaohsiung, ROC

2.Postdoctor2006.1-2006.6 Department of Medical Research, National Taiwan University Hospital and National Taiwan University College of Medicine

3.Occupational Therapist 2000-2002 Department of Rehabilitation Ping-Tung hospital ROC

4.Occupational Therapist 1996-1999 Department of Rehabilitation JEN-AI hospital Ping-Tung City ROC

Professional Membership

1.The Chinese Physiological Society membership

2.Association of Anatomists of the Republic of China membershipThe Taiwan Occupational Therapy Association

Professional Activities

1.Occupational Therapy for Physical Dysfunction

2.Functional Anatomy for occupational therapy

Research field 1: Cardiovascular system

The Mechansim of Exendin-4-based nanoparticle on acute cerebral ischemia-induced stroke injury in diabetic mellitus rats. As Glucagon-like peptide-1 (GLP-1) is a gut hormone secreted by small intestine under a fine-tune regulation in response to glucose concentration. GLP-1 exerts a glucose-dependent stimulatory effect on insulin release via binding to the GLP-1 receptor (GLP-1R) on pancreatic β-cells. GLP-1R has been reported to be ubiquitously expressed in non-pancreatic tissues including brain and cardiovascular system suggesting its important pathophysiologic role in these organs. Based on the physiological activity, GLP-1 has been clinically employed for treating patients with Type 2 diabetes. Recently, GLP-1 and its agonists have been reported to exert cardiovascular and neuronal protective activity in preclinical and clinical studies.To study whether diabetes mellitus is a major independent risk factor for induction of stroke by the mechanisms of diabetics induced oxidative stress and inflammation. The prevention of diabetic-induced stroke injury requires further studies. However, the efficiency and mechanisms of application between exedin-4 and exendin-4-load PLGA effect on diabetic-induced stroke are still uncertain. Because of possibly more efficiency on antioxidant, anti-inflammatory, and anti-apoptotic activities, and longer-acting GLP-1R analogs exendin-4 and PLGA exendin-4-load are under investigation in this study. The hypotheses will be examined in this project. First, we suggest that GLP-1R activation may evoke Bax/Bcl-2/Bcl-xL dependent mitochondrial protection and nuclear-mediated PPARβ-δ/ HO-1 signaling to protective endothelial and neuronal cells. Second, we also suggest that GLP-1 analog and GLP-1R activation may produce vasodilatory effect in the endothelial and neuronal cells through PKA-PI3K/Akt-eNOS mediated signaling to restore NO bioavailability and subsequently improve endothelial and neuronal function. In this study, we will focus on the cardiovascular or neuronal protective activity of GLP-1R agonists and analogs, with an emphasis on examining the effect on diabetes-induced cerebral acute ischemia stroke of vascular damage in and neuronal damage in ischemia/reperfusion-induced stroke through the blood flow dysregulation. We will explore the protective effect of a newly developed nano-sized PLGA exendin-4-load treatment in the middle cerebral artery occlusion induced stroke in the diabetic mellitus rats. We will determine the levels of phosphorylated NFκB forms of ICAM-1, and Akt phosphorylated forms of endothelial nitric oxide synthase (eNOS) in the diabetic-induced ischemia stroke damaged brain.

Research field 2: Digital Mirror Therapy

Mirror visual feedback (MVF) generated in mirror therapy (MT) with a physical mirror promotes the recovery of hemiparetic limbs in patients with stroke, but is limited in that it cannot provide an asymmetric mode for bimanual coordination training. Here, we developed a novel MT system that can manipulate the MVF to resolve this issue. The aims of this pilot study were to examine the feasibility of delayed MVF on MT and to establish its effects on cortical activation in order to understand how it can be used for clinical applications in the future.

Three conditions (no MVF, MVF, and 2-s delayed MVF) presented via our digital MT system were evaluated for their time-course effects on cortical activity by event-related desynchronization (ERD) of mu rhythm electroencephalography (EEG) during button presses in 18 healthy adults. Phasic ERD areas, defined as the areas of the relative ERD curve that were below the reference level and within -2-0 s (P0), 0-2 s (P1), and 2-4 s (P2) of the button press, were used.

The overall (P0 to P2) and phasic ERD areas were higher when MVF was provided compared to when MVF was not provided for all EEG channels (C3, Cz, and C4). Phasic ERD areas in the P2 phase only increased during the delayed-MVF condition. Significant enhancement of cortical activation in the mirror neuron system and an increase in attention to the unseen limb may play major roles in the response to MVF during MT. In comparison to the no MVF condition, the higher phasic ERD areas that were observed during the P1 phase in the delayed-MVF condition indicate that the image of the still hand may have enhanced the cortical activation that occurred in response to the button press.

Achieve delayed MVF for upper-limb MT. Our approach confirms previous findings regarding the effects of MVF on cortical activation and contributes additional evidence supporting the use of this method in the future for upper-limb motor training in patients with stroke.